Person tired due to narcolepsy symptoms 2

“What are the DSM-5* diagnostic criteria for narcolepsy?”

How narcolepsy is diagnosed according to the American Psychiatric Association (APA) DSM-5 criteria.

All of the following DSM-5 criteria should be met for narcolepsy patients.1

  1. Recurrent periods of an irrepressible need to sleep, lapsing into sleep, or napping occurring within the same day. These must have been occurring at least 3 times per week over the past 3 months.1
  2. The presence of at least one of the following:
    • Episodes of cataplexy, occurring at least a few times per month, and as defined by either:
      • In individuals with long-standing disease, brief (sec to min) episodes of sudden, bilateral loss of muscle tone with maintained consciousness that are precipitated by laughter or joking.1
      • In children or in individuals within 6 months of onset, spontaneous grimaces or jaw-opening episodes with tongue thrusting or global hypotonia, without any obvious emotional triggers.1
    • Hypocretin deficiency, as measured by cerebrospinal fluid (CSF) hypocretin-1 immunoreactivity values of one-third or less of those obtained in healthy subjects using the same assay, or 110 pg/mL or less.1†
    • Nocturnal sleep polysomnography (PSG) showing rapid eye movement (REM) sleep latency of 15 minutes or less, or a multiple sleep latency test (MSLT) showing a mean sleep latency of 8 minutes or less and more than 2 sleep onset rapid eye movement periods (SOREMPs).1

*DSM-5 = Diagnostic and Statistical Manual of Mental Disorders, 5th ed.

This does not include results obtained in the presence of acute brain injury, inflammation, or infection.1

Xyrem efficacy for cataplexy and EDS in narcolepsy graph icon

Learn about XYREM for cataplexy and excessive daytime sleepiness (EDS) in narcolepsy in adult and pediatric patients.