person yawning narcolepsy

“How is XYREM thought to work?”

Understanding the proposed XYREM MOA.

The mechanism of action of XYREM in the treatment of cataplexy and EDS in narcolepsy is unknown.1

  • It is hypothesized* that the therapeutic effects of XYREM on cataplexy and excessive daytime sleepiness (EDS) in narcolepsy are mediated through...1

GabaB Actions

Xyrem MOA - GABA actions
noradrenergic, dopaminergic, and thalamocortical neurons
  • at noradrenergic
  • and dopaminergic neurons,
  • as well as at thalamocortical neurons.
*Derived from animal studies.